Utchajkin V.F., Baranova E.B., Ovanesov E.N., Setsko I.V.
Clinical importance of noninvasive bilirubinemia monitoring by children viral hepatitis.
2-nd Symposiums "NoninvasiveMethods of Diagnostics". The thesis of the reports. Moscow. 1995 Oct. 30 - Nov. 2.

The transcutaneous analyzer BILITEST was used to examination of bilirubin content of 211 children from 6 to 14 years old with viral hepatitis . The measurements were carried out in various points of body. The maximal value of the device readings and maximal correlation (r = 0.9) with biochemical method were reached by measurements on sternum. For children with illnes duration up to 3 days, the noninvasive measurement results were found a little bit underestimated in comparison with real bilirubin content in blood. This may be the effect of delay in one - two days in complete painting of subcutaneous fabrics by yellow pigment. By illness duration more than 3 days there were observed no appreciable deviations between the methods. The result of noninvasive examination of bilirubinemia degree depends on such physical parameters of biofabric of the person as thickness of the skin, subcutaneous adipose tissue, skin pigmentation, amount of blood-vessels in subcutaneous cellular tissue. The variation of device readings from real bilirubin content is in dependence to individual peculiarities of physical parameters of infant biofabric. In case of insignificant bilirubinemia level the readings of BILITEST were found comparable to blood bilirubin concentration. It makes the noninvasive method usable by viral hepatitis disease only for bilirubinemia level estimation, meaning possibility of understating of measurement results in first days of disease. By noninvasive monitoring of bilirubinemia there is no essential influence by physical parameters of a biofabric to process dinamics estimation. In this case the process dynamics and view of bilirubinemia level changing, evaluated using BILITEST, correspond to clinical sympthoms of disease. Consequently, the biochemical blood research must be carried out once unconditionally at beginning of disease, and repeatedly only by results of monitoring and at presence of the clinical indications.